I simply cut the portion out that covered the 2nd mic near the headphone slot, but it would have looked a lot neater had the case been designed with that in mind. I am attaching pictures to demonstrate what I am talking about. On the positive side, it is a little thicker of a case than I realized, so the phone is actually a little better protected than I thought it would be. The case also fits the phone very well, not too tight, not too loose. It is exactly the fit I would expect with a case.
(Update) I failed to mention this is the previous review, but I own the iPhone 4S. After doing a little research, I discovered that the mute/vibrate switch is in a slightly different place.(even though the AT&T sales guy told me that the phones would be identical) This makes a difference when thinking about purchasing this case and how well the case would fit the phone's switch. I also should point out another slight qualm with this case. I had a very difficult time getting my tape adapter, and my headphones plugged into the jack on the iPhone 4S because the case comes right up to the hole.
Because headphone jacks have some girth around the plug or stem, the rubber came so close to the hole that it was preventing me from comfortably plugging the headphones into the headphone hole on the iPhone 4S. this required me to force the stem into the hole. Needless to say I was a little worried I would screw up something in the phone, so I went to work again and widened the hole in the case near the iPhone 4S headphone hole with my blade knife. It does not look incredibly pretty, but I was able to solve the problem that way.